2013 Fiscal Year Final Research Report
Analysis of ErbB4 cleavage in neuronal cells
| Project/Area Number |
24700381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
NAKAMINE Sayomi 琉球大学, 医学(系)研究科(研究院), 助教 (20381105)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | GnRH / GT1-7細胞 / ErbB4 / GPCR / PKD / Gタンパク質 |
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| Research Abstract |
Gonadotropin-releasing hormone (GnRH) is secreted from hypothalamic neurons (GnRH neurons). To investigate function of the GnRH neuron, we examined the molecular mechanisms of GnRH-induced ERK activation and ErbB4 cleavage in GT1-7 cells. We found that Gq/11 proteins, PKC, PKD, PYK2 and Fyn were involved in ERK activation, while PKD, PYK2 and Fyn did not affect ErbB4 cleavage. These results suggest that ERK activation and ErbB4 cleavage are induced by different molecular mechanisms.
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