Analysis for the transgenerational molecular mechanisms of poor maternal behavior

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700382
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Yokohama City University
• Principal Investigator: TADA Hirobumi 横浜市立大学, 医学部, 助教 (20464993)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: AMPA受容体 / アクチン / Cofilin / 内側前頭前野

Outline of Final Research Achievements

Poor maternal behaviors have often been reported to be transmitted across generations. In this program, to investigate the transgenerational molecular mechanisms of poor maternal behavior, we study the effect of early life environment in the neocortex related social behavior. We have found that early life stress disrupts synaptic AMPA receptor delivery through adulthood by changing actin dynamics in the neocortex. Furthermore, to elucidate the transgenerational molecular mechanisms, we have evaluated correlation between early life stresses, poor maternal care and synaptic AMPA receptor delivery in the neocortex.

Free Research Field

分子神経生物学