2013 Fiscal Year Final Research Report
Analysis of neural stem cell fate using whole genome methylation profile
| Project/Area Number |
24700412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fusional basic brain science
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| Research Institution | Kyushu University (2013)
Nara Institute of Science and Technology (2012) |
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Principal Investigator |
SANOSAKA Tsukasa 九州大学, 医学(系)研究科(研究院), 研究員 (40588472)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | エピジェネティクス / DNAメチル化 / 神経幹細胞 |
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| Research Abstract |
In this research, I analyzed property of neural stem cell, which change during development comparing methylation status.I collected neural stem cells from different stage (Enbryonic day 11, 14, 18) of mouse brain and differentiated cells such as neuron, astrocyte and oligodendrocyte for whole genome methylation analysis. I identified the differentially methylated region of each cell type and transcription factor binding site.
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