2013 Fiscal Year Final Research Report
Off-label drug evaluation on the newly generated animal model mice for the bipolar disorders
| Project/Area Number |
24700414
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fusional basic brain science
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| Research Institution | Fujita Health University |
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Principal Investigator |
AGETA Hiroshi 藤田保健衛生大学, 総合医科学研究所, 助教 (40416649)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | モデル動物 / アクチビン / 躁鬱病 / プロテオミクス / miRNA |
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| Research Abstract |
We previously reported that the level of activin (one member of the TGF-beta superfamily) regulates the synaptic structure, anxiety-related behavior, adult neurogenesis, late-phase LTP and memory formation. To elucidate the downstream of activin signaling in the brain, we performed comprehensive analysis of activin-dependent animal models for bipolar disorders. As a result, we detected molecular variations and posttranslational modification on the brain of these mice. Furthermore, we performed DNA array analyses for mRNA and miRNA on these mice and detected fluctuating molecules. As a next step, we will assess these factors on the treatment of off-label drugs to activin-dependent animal models, and redefine a compound as new potential therapeutics for bipolar disorder.
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