2013 Fiscal Year Final Research Report
| Project/Area Number |
24700428
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ウイルス探索 / 血漿メタゲノム解析 / ヘパチウイルス / 霊長類 / マカク / 次世代シークエンサー / 肝炎 |
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| Research Abstract |
Various genome sequences of organisms have been determined using next-generation sequencing platforms. The ortholog of Hepatitis C virus (HCV) is not determined yet although HCV was isolated as non-A, non-B hepatitis virus more than 20 years ago. The narrow host range of HCV infection hampers development of animal models for the study of HCV infection and the viral immune-pathogenesis. The chimpanzees have been employed as an animal model for HCV infection, although the use of chimpanzees is limited by ethical concerns, restricted availability and high costs. In order to overcome these hurdles, new animal models for HCV infection appear to play critical roles. In this point of view, the development of a macaque model for hepatitis C will contribute to hepatitis C research in vivo. The genome sequences of viruses were determined from plasma samples of macaques with highly alanine aminotransferase. Some viruses were detected from macaque plasma, using next generation sequencer platform.
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[Journal Article] Dynamics of cellular immune responses in the acute phase of dengue virus infection2013
Author(s)
Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Kurosawa T, Hamano M, Higashino A, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H
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Journal Title
Archives of Virology
Volume: 158
Pages: 1209-1220
DOI
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[Journal Article] Efficient in vivo depletion of CD8+ T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration2013
Author(s)
Yoshida T, Suzuki S, Iwasaki Y, Kaneko A, Saito A, Enomoto Y, Higashino A, Watanabe A, Suzuki J, Inoue K, Kuroda T, Takada M, Ito R, Ito M, Akari H
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Journal Title
Immunology Letters
Volume: 154
Pages: 12-17
DOI
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