Effects of metabolic and nutritional interaction between mother and fetus on the disease susceptibility in mouse

2013 Fiscal Year Final Research Report

• Project/Area Number: 24700440
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: FURUSE Tamio 独立行政法人理化学研究所, バイオリソースセンター, 開発研究員 (60392106)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 実験動物学 / マウス / DOHaD / 胎児期栄養

Research Abstract

Nutrient source of fetuses completely depends on supply from their mother via placenta. The nutritional environment in fetal life may affect not only growth and morbidity but also postnatal phenotypes of progeny. In this study, we aimed to examine effects of interaction between mother and fetus in pregnancy on basal metabolism and disease susceptibility of mother using mouse model. We fed AIN93G as a control diet and low protein diet (LP) as a malnutritional diet to mothers since 1 month before pregnancy to delivery. In blood biochemistry test, significant differences in blood levels of lipid, glucose, and protein were detected between mothers of LP group and AIN93G group. On the other hands, significant differences in parameters that are indicators of liver function were detected between progeny of LP group and AIN93G group. These results suggest that abnormality of nutrient transportation between mother and fetus is induced with low protein diet.

Research Products

• [Journal Article] マウス胎児期低栄養モデルを用いたDOHaD仮説の検証 (2014)
  • Author(s): 古瀬民生,若菜茂晴
  • Journal Title: 精神科 Volume: 24 Pages: 335-339
• [Journal Article] Pheno-Pub : a total support system for the publication of mouse phenotypic data on the web (2013)
  • Author(s): Suzuki T, Furuse T, Yamada I, Motegi H, Kozawa Y, Masuya H, Wakana S
  • Journal Title: Mammalian Genome Volume: 24 Pages: 473-483
  • DOI: 10.1007/s00335-013-9482-y
  • Peer Reviewed
• [Presentation] The effects of maternal malnutrition in utero on behavioral phenotypes of mouse–validation of DOHaD theory in mouse (2013)
  • Author(s): Furuse T, Yamada I, Kaneda H, Kobayashi K, Kohda T, Ishino F, Miyake K, Kubota T, Wakana S
  • Organizer: The 27th International Mammalian Genome Conference
  • Place of Presentation: Salamanca, Spain
  • Year and Date: 2013-09-17
• [Presentation] マウスモデルを用いたD OHaD仮説の評価 : 母体低栄養が産仔の行動表現に与える影響 (2013)
  • Author(s): 古瀬民生
  • Organizer: 包括脳科学研究推進支援ネットワーク夏のワークショップ
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2013-08-31
• [Presentation] マウス胎生期低栄養モデルからの知見 (2013)
  • Author(s): 古瀬民生,若菜茂晴
  • Organizer: 第2回日本DOHaD研究会年会
  • Place of Presentation: 厚生労働省戸山研究庁舎(新宿区)
  • Year and Date: 2013-06-07
• [Presentation] マウスモデルを用いたDOHaD仮説の実証2 : 母体低栄養が新生仔の行動表現型に与える影響 (2013)
  • Author(s): 古瀬民生,幸田尚,串田知子,柏村実生,山田郁子,金田秀貴,小林喜美男,石野史敏,古市貞一,久保田健夫,若菜茂晴
  • Organizer: 第60回日本実験動物学会総会
  • Place of Presentation: つくば国際会議場(つくば市)
  • Year and Date: 2013-05-15
• [Presentation] マウスモデルを用いたDOHaD仮説の実証 : 遺伝子発現パターンからみた胎生期低栄養の影響の脳—肝臓間差異 (2012)
  • Author(s): 古瀬民生,幸田尚,山田郁子,三浦郁生,金田秀貴,小林喜美男,石野史敏,久保田健夫,若菜茂晴
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2012-09-21
• [Presentation] マウスモデルを用いたDOHaD仮説の検証その1 : 母体低栄養が新生児の出生体重と遺伝子発現に与える影響 (2012)
  • Author(s): 古瀬民生,幸田尚,串田知子,山田郁子,金田秀貴,小林喜美男,石野史敏,久保田健夫,若菜茂晴
  • Organizer: 第26回モロシヌス研究会
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2012-06-15
• [Presentation] マウスモデルを用いたDOHaD仮説の実証1 : 母体低栄養が新生児の出生体重と遺伝子発現に与える影響 (2012)
  • Author(s): 古瀬民生,幸田尚,串田知子,山田郁子,尾崎藍,金田秀貴,石野史敏,久保田健夫,若菜茂晴
  • Organizer: 日本実験動物科学・技術九州2012
  • Place of Presentation: 別府コンベンションセンター(別府市)
  • Year and Date: 2012-05-24