Quantification of physiological parameters in brain PET: partial volume correction and denoising

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700445
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tohoku University
• Principal Investigator: SHIDAHARA Miho 東北大学, 医学(系)研究科(研究院), 講師 (20443070)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳PET / 画像処理 / 動態解析

Outline of Final Research Achievements

Towards more accurate estimation of physiological brain function using PET, we developed the methodology SFS-RR (structural and functional synergy for resolution recovery), which improves image quality (both resolution and quantification) of PET image by using Wavelet transform and anatomical/structural information (MRI and brain atlas images). We evaluate the performance of the recovery strategy in the case of the quantification of dopaminegic function in striatal regions. The proposed methodology proved effective in the resolution recovery of small structures of brain [11C]raclopride PET images and the improvement is consistent across the anatomical variability of a simulated population (Shidahara et al, 2012).

Free Research Field

核医学