Synthesis of a resin monomer soluble polyrotaxane crosslinker containing cleavable end groups for dental application

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700477
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SEO JI-HUN 東京医科歯科大学, 生体材料工学研究所, 助教 (20611544)
• Research Collaborator: YUI Nobuhiko 東京医科歯科大学, 生体材料工学研究所, 教授 ; HIRATA Koichiro (株)トクヤマデンタル, 研究所所長 ; NAKAGAWA Shino (株)トクヤマデンタル, 研究所研究員
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯科用材料 / ポリロタキサン / 超分子化学

Outline of Final Research Achievements

A resin monomer-soluble polyrotaxane (PRX) crosslinker with cleavable end-groups was synthesized to develop degradable dental composite resins. The PRX containing 13 n-butyl group per CD molecule was completely soluble in conventional resin monomers such as 2-hydroxyethyl methacrylate (HEMA) and urethane dimethacrylate (UDMA). The synthesized n-butyl-introduced PRX was further modified with 2-aminoethyl methacrylate to provide crosslinkable acrylic groups onto PRX. The prepared resin monomer-soluble PRX crosslinker was successfully polymerised with a mixture of HEMA and UDMA to provide photosetting plastic. It was confirmed that the Vickers hardness of the prepared plastic was greatly decreased after treatment with dithiothreitol. This indicates that the resin monomer-soluble PRX crosslinker can be applied to design degradable photosetting plastics potentially used in industrial or biomedical field.

Free Research Field

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