2017 Fiscal Year Final Research Report
Effect of exercise on muscle atrophy in diabetic rat
| Project/Area Number |
24700525
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Research Collaborator |
YAMAZAKI Toshiaki
HOSO Masahiro
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| Project Period (FY) |
2013-02-01 – 2018-03-31
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| Keywords | 糖尿病ラット / 廃用性筋萎縮 / 運動効果 |
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| Outline of Final Research Achievements |
The objective of the present study was to create disuse muscle atrophy in Goto-Kakizaki rats (GK rats), which are a type of non-obese type 2 diabetes model rat, using hindlimb suspension. We then investigated the effects of reloading. The target muscles were the soleus muscle and the plantaris muscle. Hematoxylin-eosin staining was performed and the samples were observed using an optical microscope. We used the image analysis software ImageJ to measure the cross-sectional areas. Investigation of myofiber cross-sectional area for GK rat soleus muscle samples showed the same trend as Wistar rat soloeus muscle samples. However, investigation of plantaris muscles in GK rats indicated that the suspension group and the reload group had significant decreases compared to those in the control group. No significant differences were found between suspension group and reload group.
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| Free Research Field |
リハビリテーション科学
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