Development of ultrasound-induced phonophoresis to promote scar healing

2015 Fiscal Year Final Research Report

• Project/Area Number: 24700530
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kobe University
• Principal Investigator: Maeshige Noriaki 神戸大学, 保健学研究科, 助教 (90617838)
• Research Collaborator: TORII Kazuhiro ; TABUCHI Hiroto ; SAKA Ayumi ; ARAKI Kyoko ; KOGA Yuka ; OCHI Akane ; UEMURA Mikiko
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 超音波 / 短鎖脂肪酸 / 線維化 / 線維芽細胞

Outline of Final Research Achievements

We elucidated the ultrasound parameters to promote the antifibrogenic and anti-inflammatory effects by short chain fatty acids. Butyrate is a fatty acid having the most potent physiological action among short chain fatty acids. We found the antifibrogenic effects of butyrate in human dermal fibroblasts, keloid fibroblasts and pterygium fibroblasts, and facilitatory effects of low-intensity ultrasound (0.1-0.5 W/cm2) for the antifibrogenic and anti-inflammatory effects by butyrate. In addition, we found the promotional effects of low-intensity ultrasound on histone acetylation by a low-concentration of butyrate.

Free Research Field

リハビリテーション科学