2014 Fiscal Year Final Research Report
Pathologic alterations in motoneuron in experimental diabetic animal
| Project/Area Number |
24700564
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Health Science University |
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Principal Investigator |
MURAMATSU Ken 健康科学大学, 健康科学部, 准教授 (00531485)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 糖尿病性ニューロパチー / 運動ニューロン / 筋紡錘 |
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| Outline of Final Research Achievements |
Alterations in the number and size of motoneurons were studied in the medial gastrocnemius (MG) motor nucleus of diabetic rats and age-matched controls. MG motoneurons were retrogradely labeled and the number and size of cell bodies were examined. Additionally, we investigate the prevention effect of 20 weeks of exercise training on motoneuronal loss in diabetic rats.
Significantly fewer labeled MG motoneurons were found in diabetic rats as compared with control animals. The size distribution of MG nucleus was bimodal; cells with larger size were presumed to be alpha-motoneurons and those with smaller were presumed to be gamma. Compared to control animals, the number of smaller MG motoneurons was reduced in diabetic animals but exercise training prevent decrease the number of MG motoneurons.We conclude that there is a significant decrease occurred predominantly among the smaller gamma- motoneurons and there is a possibility that exercise training prevent these motoneuronal loss.
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| Free Research Field |
糖尿病性ニューロパチーの病態生理
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