Exercise training facilitates recovery from muscle atrophy by stimulating proliferation of myogenic satellite cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700566
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagoya Gakuin University
• Principal Investigator: ITOH Yuta 名古屋学院大学, リハビリテーション学部, 助教 (30454383)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: リハビリテーション科学 / 運動療法学 / 動物 / 細胞生物学 / 骨・筋肉

Outline of Final Research Achievements

To know the cellular mechanism of exercise-dependent facilitating recovery of atrophied muscle, I examined the effects of exercise on the number of nuclei of individual myofibers in atrophied and normal muscles. Results, the exercise promoted recovery of atrophied myofiber CSA, and the number of newly generated myonuclei increses. And proliferation, differentiation and fusion of myogenic satellite cells were observed, suggesting that the activation of myogenic satellite cells induced by exercise effectively facilitate the recovery of size of myofibers from the muscle atrophy.

Free Research Field

総合領域