2014 Fiscal Year Final Research Report
The molecular mechanism of neural network reorganization after stroke
| Project/Area Number |
24700572
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
OKABE Naohiko 川崎医科大学, 医学部, 助教 (30614276)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | リハビリテーション / 脳梗塞 |
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| Outline of Final Research Achievements |
It has been well known that the neural network is reorganized after cerebral infarct to compensate the lost function. However, the mechanism underlying the neural network reorganization is not known. In previous study, we found that the rehabilitation therapy causes the secondary motor cortex forelimb area expansion after cerebral infarct in primary motor cortex forelimb area in rat. Anatomical analysis revealed that the rehabilitation therapy enhanced axon growth in spinal cord, suggesting rehabilitation therapy induces motor map reorganization by promoting axon remodeling in spinal cord.
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| Free Research Field |
リハビリテーション科学・福祉工学
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