Effect of muscle contraction mode on intracellular signaling-related muscle hypertrophy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700703
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Juntendo University
• Principal Investigator: KAKIGI RYO 順天堂大学, 医学部, 助教 (70614931)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 筋収縮様式 / 細胞内シグナル伝達 / 筋線維組成

Outline of Final Research Achievements

The aim of this study was to clarify the effect of muscle contraction mode on intracellular signaling involved in protein synthesis and muscle hypertrophy in human skeletal muscle. We demonstrated that maximal eccentric muscle contraction exercise rather than concentric and isometric contraction exercise stimulates mammalian target of rapamycin (mTOR) signaling in untrained skeletal muscle. In addition, the increase of mTOR signaling after eccentric contraction occurred mainly in Type I and IIa muscle fiber. These results suggest that training with eccentric contraction may be effective methods to increase muscle protein synthesis and muscle mass in the early phase of exercise intervention.

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