2013 Fiscal Year Final Research Report
Identification of microRNAs as molecular targets for the prevention and treatment of skeletal muscle atrophy
| Project/Area Number |
24700772
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
|---|
Principal Investigator |
FUJITA Yasunori 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30515888)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 筋萎縮 / microRNA |
|---|
| Research Abstract |
In an attempt to identify novel molecular targets for the prevention and treatment of skeletal muscle atrophy, we searched microRNAs associated with skeletal muscle atrophy using both cell culture and animal models. Our results showed that miR-503 regulated the expression of muscle atrophy-related genes and that miR-196a, whose expression was decreased in the skeletal muscle of aged rats and mice, was associated with oxidative stress response. More detailed analysis would reveal the usefulness of these microRNAs as molecular targets for skeletal muscle atrophy.
|
