Investigation into the Relationship between Andropause and Sarcopenia and Establishment of the Methods to Prevent its Occurrence by the Physical Activity

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700775
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Kochi University (2013-2014); National Center for Geriatrics and Gerontology (2012)
• Principal Investigator: YUKI ATSUMU 高知大学, 教育研究部人文社会科学系, 助教 (00623224)
• Co-Investigator(Renkei-kenkyūsha): SHIMOKATA Hiroshi 名古屋学芸大学, 教授 (10226269) ; ANDO Fujiko 愛知淑徳大学, 健康医療科学部, 教授 (90333393)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: NILS-LSA / DXA / テストステロン

Outline of Final Research Achievements

We assessed longitudinal relationships between baseline testosterone and muscle mass changes in Japanese men. We also examined whether physical activity inhibited the Sarcopenia caused by Andropose. Data from NILS-LSA(National Institute for Longevity Sciences, Longitudinal Study of Aging) was analyzed longitudinally. The association of the free Testosteron (T) levels with the loss of muscle mass was significant. Moreover, muscle mass was affected by serum levels of free T in middle-aged and elderly Japanese people who have the Long allele of the Androgen Receptor CAG microsatellite. The moderately physical activity (2.5-4.4METs) in leisure time inhibited the loss of muscle mass caused by Andropose.

Free Research Field

体力科学