2013 Fiscal Year Final Research Report

Analysis of mechamisms in brain tumor stem cell regulation by polyphenol

Research Project

Project/Area Number	24700824
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Eating habits, studies on eating habits
Research Institution	Gifu University
Principal Investigator	IKEGAME Yuka 岐阜大学, 医学(系)研究科(研究院), 助教 (50402201)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	ポリフェノール / 脳腫瘍幹細胞
Research Abstract	Resveratrol (RSV) is a natural polyphenolic compound, present in plants and food made from plants, that can cross the blood-brain barrier. Glioblastoma (GBM) is the most malignant primary brain tumor, which is known to have cancer stem cells (CSCs). CSCs appear to be an important cause of GBM's formidable resistance to various therapies, such as chemical agents or radiation. In the present study, RSV's anti-tumor effects against CSCs in GBM (U87 cells) and mechanisms including Sirtuin (SIRT) genes were indicated. The results from analyses of morphological changes and expressed proteins indicated: (1) RSV can induce GBM-CSC differentiation, which could make GBM more responsive to therapies; (2) RSV's anti-tumor effects on GBM may include mechanisms related to the activation or inactivation of SIRT genes (SIRT 1, 2, 3, 6) that induce CSC differentiation, which contribute to reduction of the malignancy, and cell death.

(2 results)