2013 Fiscal Year Final Research Report

The elucidation of the effect of T-cell and mechanism of metabolic syndrome by dietary composition

Research Project

Project/Area Number	24700828
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Eating habits, studies on eating habits
Research Institution	The University of Tokushima
Principal Investigator	SHUTO Emi 徳島大学, ヘルスバイオサイエンス研究部, 講師 (10512121)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	メタボリックシンドローム / 大豆イソフラボン / 慢性炎症
Research Abstract	Metabolic syndrome is the underlying disease proceed crirical disorder, diabetes, stroke, et al. Nearly, it was reported that T cell-infiltrated in adipose tissues was regulated differentiation of macrophage, so macrophage was dictated chronic inflammation in adipose tissue and whole-body. We ever reported about immune function of soy isoflavone. In this study, we examined effect of Soy isoflavones on the inflammation in diet indused obesity mice. Soy isoflavones were ameliorated glucose metabolism and lipid metabolism, and declining trend to accumulation of body fat. In particular, Equol was significantly inhibited expression of gene associated macrophage. Thus, it is suggested that soy isoflavone might be possible to prevent metabolic syndrome.