Effect of aging and lifestyle disease on protein arginine methylation and Alzheimer's disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24700840
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: University of Kochi (2014); Okayama Prefectural University (2012-2013)
• Principal Investigator: SUZUKI Makiko 高知県立大学, その他部局等, 准教授 (60437001)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アルギニンメチル化 / PRMT / マウス脳

Outline of Final Research Achievements

5 week-old mice were assigned to two groups fed with normal diet or high-fat diet for 65 weeks. High-fat diet group was induced insulin resistance. Expression of Protein arginine methyltransferase 1 (PRMT1) were decreased by both high-fat diet and aging. Expression of CARM1, an isoform of PRMTs was decreased by aging. Although expression of Sam 68 which is a substrate for PRMT1 was not affected by high-fat diet and aging, arginine methylation of component protein of Sam 68 complex was up-regulated by both high-fat diet and aging.

Free Research Field

分子病態栄養学