2013 Fiscal Year Final Research Report
Effect of n-3 fatty acids supplementation on hepatic phospholipid metabolism in nonalcoholic steatohepatitis.
| Project/Area Number |
24700852
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Fukuyama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | NASH / 非アルコール性脂肪性肝炎 / n-3系脂肪酸 |
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| Research Abstract |
Feeding a diet deficient in both methionine and choline (MCD) is one of the most common models of nonalcoholic steatohepatitis (NASH). We analyzed the effects of n-3 fatty acids (FA) supplementation on the hepatic phospholipids and injury in MCD fed mice. n-3 FA improved plasma transaminase levels and hepatic triglyceride accumulation in the MCD model of NASH. n-3 FA supplementation also changed liver phospholipids FA composition, not only polyunsaturated fatty acid but also saturated fatty acid.
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