2015 Fiscal Year Final Research Report
A study on rice extract potentiating intestinal immune system for prevention of allergy.
| Project/Area Number |
24700863
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Shujitsu University (2014-2015)
岡山県農林水産総合センター生物科学研究所 (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 食品機能 / 米 / 腸管免疫 / パイエル板 / Th1/Th2 |
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| Outline of Final Research Achievements |
The prevention or modulation of immune response through the regulation of Th2 type helper T cell differentiation is recently demonstrated to attenuate symptoms which related to allergy. Here, we investigated the effect of brown rice extracts (BRE) on IFN-γ production from mice splenocytes. The treatment of BRE dose-dependently increased IFN-γ. In order to determine the active component, we separated BRE by ultrafiltration. High molecular weight fraction enhanced IFN-γ production. We further examined whether oral administration of BRE could have a beneficial effect on immune system in ovalbumin (OVA)-immunized mice. The oral administration of BRE dose-dependently induced IFN-γ production by splenocytes. Total and OVA-specific IgE in serum of mice, which were administrated BRE, was lower than that of the OVA-immunized mice. These results suggest that BRE might improve the Th1/Th2 balance toward Th1 dominance.
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| Free Research Field |
食品機能学
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