2013 Fiscal Year Final Research Report
Molecular mechanism of prostate cancer metastasis to bone
| Project/Area Number |
24700967
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
EHATA Shogo 東京大学, 医学(系)研究科(研究院), 講師 (90506726)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 転移 |
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| Research Abstract |
Functional interactions between cancer cells and the bone microenvironment contribute to the development of bone metastasis. Although the bone metastasis of prostate cancer is characterized by increased ossification, the molecular mechanisms involved in this process are not fully understood. Here, the roles of bone morphogenetic proteins (BMPs) in the interactions between prostate cancer cells and bone stromal cells were investigated.
Our findings suggest that BMPs provide favorable circumstances for the survival of prostate cancer cells and the differentiation of bone stromal cells in the bone microenvironment, possibly leading to the osteoblastic metastasis of prostate cancer.
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