2013 Fiscal Year Final Research Report
Regulation of EGF signaling transduction in breast cancer-initiating cells and their niches
| Project/Area Number |
24700968
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIZUTANI ANNA 東京大学, 医学(系)研究科(研究院), 特任研究員 (30615159)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | がん幹細胞 / 乳がん |
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| Research Abstract |
Recently cancer-initiating cells have been considered to be important targets in chemotherapy. Our data using breast cancer cell lines shows transforming growth factor (TGF)-beta signaling is involved in cancer-initiating like cell maintenance in addition to epidermal growth factor (EGF) and fibroblast growth factor (FGF) signaling. We previously showed that epithelial splicing regulatory protein (ESRP) was transcriptionally down-regulated by TGF-beta. ESRPs are involved in mRNA splicing widely. We investigated the regulatory mechanisms of ESRPs. Here we obtained the data which could be a clue to understand the regulatory mechanism of ESRPs.
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