2013 Fiscal Year Final Research Report
The functional analysis of novel long non-coding RNA regulating p53
| Project/Area Number |
24700975
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ノンコーディングRNA / 細胞増殖 |
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| Research Abstract |
In this study, we aimed the functional analysis of long non-coding RNA, POLOP (Positive regulator lncRNA of p53). We found that POLOP highly expresses in human osteosarcoma cells. The expression of POLOP was induced by the treatment of etoposide and forced expression of H-RASG12V. The depletion of POLOP in human osteosarcoma cells decreased cell growth. These results suggest that POLOP promotes the cell growth of human osteosarcoma cells.
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Research Products
(18 results)
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[Journal Article] The amelioration of renal damage in Skp2-deficient mice canceled by p27 Kip1 deficiency in Skp2-/- p27-/- mice2012
Author(s)
Sayuri Suzuki, Hirotaka Fukasawa, Taro Misaki, Akashi Togawa, Naro Ohashi, Kyoko Kitagawa, Yojiro Kotake, Ning Liu, Hiroyuki Niida, Keiko Nakayama , Keiichi I. Nakayama, Tatsuo Yamamoto and Masatoshi Kitagawa
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Journal Title
PLoS One
Volume: 7(4)
Pages: e36249
Peer Reviewed
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