2013 Fiscal Year Final Research Report
Anti-tumor effects of combination dosage of kinase inhibitors and analysis of synergistic control molecular mechanism.
| Project/Area Number |
24700977
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University (2013)
Kyoto University (2012) |
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Principal Investigator |
AKAMATSU KANAKO 大阪大学, 医学(系)研究科(研究院), 研究員 (90553967)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | kinase inhibitor / combination dosage / molecular mechanism |
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| Research Abstract |
I analyzed an anti-tumor mechanism through a variability analysis in vivo. In this study, I focused on two-species mixture drugs treatment; combination of two-species drugs has intense anti-tumor effect, whereas both drugs are ineffective in tumor suppression when it is used as a sole regimen. Through the about 30000 spices chemical assay, I discovered two candidate drugs, C053 and C127, which showed a drastic decrease in cell survivals. Although a structure activity correlation assay, and a variability analysis of C053 did not uncover a totally new apoptotic pathway, I found some combinations of established drug and C053 strongly induced apoptosis. This finding has a possibility for new drug discovery and medical applying for drug resistance caner cells.
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