2013 Fiscal Year Final Research Report
Tumorigenesis triggered by the misregulation of cell polarity associated with cell cycle
| Project/Area Number |
24700980
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
KIKUCHI Koji 熊本大学, 生命科学研究部, 助教 (70457290)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 細胞運動 / 前後極性 / 上皮極性 / 微小管動態 / MAP7ファミリー / Wnt5aシグナル / Dvl2 |
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| Research Abstract |
The establishment and maintenance of cell polarity has a crucial role in multiple biological processes from chemotaxis to embryogenesis, and the abnormality of cell polarity promotes tumorigenesis. It is believed that cytoskeletal network between microtubule (MT) and filamentous actin plays an important role for the establishment and maintenance of cell polarity. However, molecular mechanisms of the cytoskeletal network still remain unclear. Here, we found that MT co-sedimented proteins, which we have previously identified, are involved in the establishment of cell polarity by regulating the cytoskeletal network.
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Research Products
(13 results)
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[Journal Article] Structure-specific endonucleases Xpf and Mus81 play overlapping but essential roles in DNA repair by homologous recombination2013
Author(s)
Kikuchi, K., Narita, T., Van, P.T, Iijima, J., Hirota, K., Keka, I.S., Mohiuddin, M., Okawa, K., Hori, T., Fukagawa, T., Essers, J., Kanaar, R., Whitby, M.C., Sugasawa, K., Taniguchi, Y., Kitagawa, K., and Takeda, S
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Journal Title
Cancer Res
Volume: 73
Pages: 4362-4371
Peer Reviewed
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