2013 Fiscal Year Final Research Report
Identification of key factors of glioblastoma tumorigenesis
| Project/Area Number |
24700986
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 癌 / 遺伝子 / 細胞・組織 |
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| Research Abstract |
The goal of this study was to investigate the characteristics of glioma-initiating cells (GICs) and identify key factors regulating the formation of glioblastoma. Using our syngeneic murine model, we conducted research as follows.
(1) We established several GIC clones and analyzed their basic properties, such as proliferation,invasion and ability to induce microvascular proliferation. As a result, we found that metabolic characteristics such as glucose consumption and lactic acid production can differ significantly between clones. (2) We analyzed the gene expression profile of our GIC clones and identified factors involved in the regulation of their metabolic characteristics. (3) We performed a functional analysis of the data obtained in (1), (2) and showed that GICs can use not only glycolysis, but also oxidative phosphorylation during glioblastoma formation.
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[Journal Article] Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model2014
Author(s)
Saga I, Shibao S, Okubo J, Osuka S, Kobayashi Y, Yamada S, Fujita S, Urakami K, Kusuhara M, Yoshida K, Saya H, Sampetrean O
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Journal Title
Neuro-Oncology
Volume: (in press)
Peer Reviewed
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