2013 Fiscal Year Final Research Report
Development of a novel cancer immunotherapy based on efficient induction of memory T cells.
| Project/Area Number |
24700991
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor immunology
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| Research Institution | Osaka University |
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Principal Investigator |
FUJIKI Fumihiro 大阪大学, 医学(系)研究科(研究院), 特任助教 (40456926)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | メモリーT細胞 / 癌免疫療法 / WT1 / CTL / ヘルパーT細胞 |
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| Research Abstract |
The induction of tumor-associated antigens (TAAs)-specific memory T cell and its maintenance are essential for ideal cancer immunotherapy. However, mechanism of memory T cell development remains unclear. In this study, we investigated the role of gene A in a murine Listeria monocytogenes infection model. As expected, gene A-deficient T cells exhibited high level of CD127 and CD62L expression after infection, leading to enhanced memory T cell formation. In addition, gene A-deficient memory T cells showed enhanced proliferative response after secondary infection.
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[Journal Article] Establishment of HLA-DR4 transgenicmice for the identification of CD4+ Tcell epitopes of tumor-associatedantigens2013
Author(s)
Yatsuda J, Irie A, Harada K, MichibataY, Tsukamoto H, Senju S, Tomita Y,Yuno A, Hirayama M, Abu Sayem M,Takeda N, Shibuya I, Sogo S, Fujiki F,Sugiyama H, Eto M, Nishimura Y
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Journal Title
PLoS One
Volume: 8
Pages: e84908
DOI
Peer Reviewed
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