2013 Fiscal Year Final Research Report
Analysis of functional defects in tumor-specific CD4+ T cells in aged animals
| Project/Area Number |
24700994
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor immunology
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| Research Institution | Kumamoto University |
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Principal Investigator |
AWAI Hirotake (TSUKAMOTO Hirotake) 熊本大学, 大学院生命科学研究部, 助教 (10433020)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 免疫老化 / CD4+ T細胞 / IL-6 / Th1 |
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| Research Abstract |
This study demonstrated that systemic increase of IL-6 was an extrinsic factor counteracting tumor-specific Th1 differentiation, and was responsible for the age-associated defect in mounting protective immunity against the tumor in aged animals. Further analysis revealed that IFN-gamma from tumor-specific Th1 cells was indispensable for the beneficial effects of IL-6 blockade on anti-tumor immune responses in aged hosts.
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Research Products
(13 results)
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[Journal Article] LY6K-specific CD4^+ T-cell immunity in patients with malignant tumor : Identification of LY6K long peptide encompassing both CD4^+ and CD8^+ T-cell epitopes2014
Author(s)
Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M. Irie A., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Daigo Y., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
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Journal Title
Oncoimmunology
Volume: (In press)
Peer Reviewed
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[Journal Article] Identification of CDCA1 long peptides bearing both CD4+ and CD8+ T-cell epitopes : CDCA1-specific CD4+ T-cell immunity in cancer patients2014
Author(s)
Tomita Y., Yuno A., Tsukamoto H., Senju S., Yoshimura S., Osawa R., Kuroda Y., Hirayama M., Hamada A., Jono H., Irie A., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
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Journal Title
Int. J . Cancer
Volume: 134
Pages: 352–366
Peer Reviewed
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[Journal Article] Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens2013
Author(s)
Yatsuda J., Irie A., Harada K., Michibata Y., Tsukamoto H., Senju S., Tomita Y., Yuno A., Hirayama M., Abu Sayem M., Takeda N., Shibuya I., Sogo S., Fujiki F., Sugiyama H., Eto M. and Nishimura Y.
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Journal Title
PLoS One
Volume: 8
Pages: e84908
Peer Reviewed
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[Journal Article] Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes : KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor2013
Author(s)
Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M., Irie A., Kawahara K., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
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Journal Title
Clin. Cancer Res.
Volume: 15
Pages: 4508-4520
Peer Reviewed
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[Journal Article] Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells2013
Author(s)
Horlad, H., Fujiwara, Y., Takemura, K., Ohnishi, K., Ikeda, T., Tsukamoto, H., Mizuta, H., Nishimura, Y., Takeya, M., Komohara, Y.
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Journal Title
Mol. Nutr. Food Res.
Volume: 57
Pages: 1046-1054
Peer Reviewed
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