2013 Fiscal Year Final Research Report
Development of new hepatocellular carcinoma treatment method using a fatty acid synthesis inhibitor
| Project/Area Number |
24701020
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 肝癌 / 脂肪酸合成酵素阻害剤 |
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| Research Abstract |
Fatty acid synthase is highly expressed in many kinds of human cancers. Cerulenin, a natural inhibitor of fatty acid synthase, induced apoptosis in human hetatic cancer cell line Huh7, Hep3B and HepG2. Next, we made orthotopic xenograft model of human liver cancer Huh7, Hep3B and HepG2.Treatment effect is now under review.Based on these studies, inhibiting fatty acid synthase would be an effective strategy to treat unresectable hepatic cancer tumor.
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