2013 Fiscal Year Final Research Report
development of hepatocellular carcinoma novel therapeutics that target wnt signaling and dUTPase
| Project/Area Number |
24701024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | dUTPase / EpCAM / β-catenin / Wnt / HCC |
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| Research Abstract |
Examples of drugs having dUTPase inhibitory effect was identified as a component of the Chinese herb Lithospermum a beta-HIVS. Create a similar compound of HIVS, it was confirmed liver cancer cell growth inhibitory effect. I have revealed a positive correlation of expression of dUTPase and EpCAM. In suppression of the expression of beta-catenin, the observed decrease in activity dUTpase promoter, expression of dUTPase found the possibility of being regulated in Wnt signaling, a strong expression of dUTPase activation of Wnt signaling.
The apparent correlation of EpCAM and Wnt / beta-catenin signaling and dUTPase, dUTPase as inhibitors, were identified, create a beta-HIVS similar compounds.
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