2013 Fiscal Year Final Research Report
Is local chemohyperthemia also feasible for metastatic lymph node?
| Project/Area Number |
24701027
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 癌 / 転移リンパ節 / 温熱化学療法 |
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| Research Abstract |
We have developed docetaxel-embedded magnetoliposome (DML) and reported its feasibility for tumor local chemo-hyperthermia with induction heating. In our report, this treatment have seemed to be effective not only to tumor local but also to metastatic lymph node. We examined whether this treatment was feasible also for metastatic lymph node or not in this study. DMLs were not accumulated in metastatic lymph nodes as our expected, thus, we newly developed micro-bubble liposome. We clarified its effectiveness for more accumulation to metastatic lymph node than DML. We have continued this study using micro-bubble liposome.
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