2013 Fiscal Year Final Research Report
Clinical significance and therapeutic potential of microRNAs in hepatocellular carcinoma
| Project/Area Number |
24701029
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Clinical oncology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
MORITA Kazutoyo 九州大学, 医学(系)研究科(研究院), 研究員 (00608862)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | microRNA / 肝細胞癌 |
|---|
| Research Abstract |
We identified key microRNAs in recurrent cases of hepatocellular carcinoma after living donor liver transplantation.
MiR-18a expression was increased, and miR-199a-5p expression was decreased in HCC and metastasis. High levels of miR-18a expression correlated with high levels of tumor markers, larger tumor size, and a high recurrence rate. Lower miR-199a-5p expression levels correlated with high levels of tumor marker levels, portal venous invasion, and a high recurrence rate. In HCC cells, miR-18a regulated the expression of tumor necrosis factor alpha induced protein 3 (TNFAIP3), and miR-199a-5p regulated the expression of hypoxia-inducible factor 1 alpha (HIF1A), vascular endothelial growth factor A (VEGFA), insulin-like growth factor 1 receptor (IGF1R), and insulin-like growth factor 2 (IGF2).
Increased miR-18a levels and decreased miR-199a-5p levels are involved in progression and poor prognosis of HCC and affect the expression of multiple genes.
|
