Elucidation of tissue-dependent chromosome aberration frequencies induced by ionizing radiation exposure to the fetus

2014 Fiscal Year Final Research Report

• Project/Area Number: 24710067
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Radiation Effects Research Foundation
• Principal Investigator: HAMASAKI Kanya 公益財団法人放射線影響研究所, 遺伝学部, 研究員 (80443597)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射線 / 胎児期被ばく / 染色体異常 / 甲状腺上皮細胞 / 脾臓Ｔリンパ球 / 造血幹細胞 / 遺伝子発現

Outline of Final Research Achievements

The data of fetal biological responses to ionizing radiation are essential for discussing the cancer risks following fetal exposure to radiation. In this study, we examined the chromosome aberration frequency in both thyroid and spleen T lymphocytes of adult mice that X ray-irradiated as fetuses. Our previous and current results indicate that the frequencies of chromosome aberration induced by fetal irradiation vary with the differences of tissues and irradiation period. Thus, it is suggested that the fetal radio-sensitivity is complicated.

Free Research Field

細胞遺伝学