Developmental neurotoxic effects of perinatal exposure to flame retardants on the behavior of adult male mouse offspring

2014 Fiscal Year Final Research Report

• Project/Area Number: 24710068
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Gunma University
• Principal Investigator: HAIJIMA ASAHI 群馬大学, 医学(系)研究科(研究院), 助教 (70555672)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 発達神経毒性 / PFOS / 行動試験

Outline of Final Research Achievements

The aim of this study was to investigate the developmental neurotoxic effects of perinatal exposure to flame retardants, perfluorooctane sulfonic acid (PFOS) and decabromodiphenyl ether (DBDE) on the behavior of adult male mouse offspring. PFOS-exposed animals showed poor performance in learning and memory tasks and Rotarod test. Because a series of neurochemical/histological studies have revealed the disrupted cerebellar and hippocampal development by PFOS exposure, these behavioral abnormalities may have induced through of functional disruption of these brain regions. Concerning DBDE exposure, no obvious abnormal behavior was observed in the present study.

Free Research Field

行動毒性学