2013 Fiscal Year Final Research Report
An on-chip hepatic metabolism model for pharmacokinetic studies
| Project/Area Number |
24710141
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | Tokai University |
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Principal Investigator |
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| Research Collaborator |
FUJII Teruo 東京大学, 生産技術研究所, 教授 (30251474)
SAKAI Yasuyuki 東京大学, 生産技術研究所, 教授 (00235128)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | マイクロ流体デバイス / バイオＭＥＭＳ / 肝代謝モデル |
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| Research Abstract |
In this project, we have established novel microfluidic technologies toward an in vitro metabolism assay platform as an alternative method of animal tests. 1) A fabrication method of an encapsulated three-dimensional cell structure in the microfluidics has been proposed to construct the metabolism model by a biomimetic approaches. 2) An microfluidic device to evaluate functions of the metabolism model has been developed, and the performance of the device was successfully tested using a prodrug.
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