2014 Fiscal Year Final Research Report
Role of acetylation of transcription factor CRP in network of metabolic regulation
| Project/Area Number |
24710214
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genome biology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | CRP / アセチル化 / RMF / 100Sリボソーム / Genomic SELEX / RNAポリメラーゼ / ゲノム転写制御 / 大腸菌 |
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| Outline of Final Research Achievements |
It was observed that the variation of acetylation level of CRP (cAMP receptor protein) along growth phase and examined the effect of acetylated CRP for promoter activity of under regulated genes in Escherichia coli. We succeeded the identification of the genome distribution of CRP and RNA polymerase. It is useful to understand the molecular mechanism of transcriptional regulation of E.coli genome. It is also revealed that CRP enhanced formation of 100S ribosome by transcriptional activation of rmf (ribosome modulation factor).
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| Free Research Field |
ゲノム転写制御
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