2013 Fiscal Year Final Research Report
Feedback regulation of epigenome by metabolism upon adaptation to nutrition environment
| Project/Area Number |
24710225
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 代謝ネットワーク / エピゲノム / 生活習慣病 |
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| Research Abstract |
Purpose of this study is to identify epigenetic regulation of cellular metabolism upon adaptation to nutrition environment and feedback regulation of epigenome by metabolism. Next generation sequence analysis revealed histone methyltransferase SETDB1 regulates metabolic switch during adipogenesis, and histone demethylases JMJD1A regulates energy expenditure in brown adipose tissue. Furthermore, metabolome analysis suggested the possibility of epigenome regulation by TCA cycle metabolite a-ketoglutarate during adipogenesis.
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