computational modelling of the entrainment of the mammalian cell cycle by the circadian clock

2015 Fiscal Year Final Research Report

• Project/Area Number: 24710230
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: System genome science
• Research Institution: Yamaguchi University
• Principal Investigator: Faure Adrien 山口大学, 理工学研究科, 助教 (00610627)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: cell cycle / circadian rhythms / logical modeling / regulatory network / circuit functionality

Outline of Final Research Achievements

The initial aim of this project was to create a model coupling the circadian clock and the cell cycle networks. However, such a coupled model was published by Gerard and Goldbeter during the first year of this project. This unexpected turn of event led to substantial modifications of the initial project. Gerard and Goldbeter's model was used as a template to produce a logical model, with the prospect of applying tools and methods available in the logical formalism to analyze entrainment of the cell cycle by the circadian clock. This proved more difficult than expected, partly due to the complexity of the original model, and partly because preliminary results highlighted limitations in the circuit functionality analysis method. Nonetheless, within the context of this project, a new model of the mammalian cell cycle has been developed, and the corresponding paper has just been accepted to the ECCB 2016 conference, to be published in a forthcoming issue of Bioinformatics.

Free Research Field

Bioinformatics