2013 Fiscal Year Final Research Report
Studies on the biosynthesis of the notoamides family of prenylated indole alkaloids
| Project/Area Number |
24710252
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Kumamoto University |
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Principal Investigator |
KATO Hikaru 熊本大学, 生命科学研究部(薬学系), 助教 (20547129)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 生合成 / インドールアルカロイド / Aspergillus / 取込実験 |
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| Research Abstract |
The notoamides are a family of prenylated indole alkaloids produced by the marine-derived Aspergillus sp. To understand the molecular bases for their biogenesis, we conducted a precursor incorporation experiment using synthetic, [13C,15N]-notoamide S. Unfortunately, compounds containing a bicycle[2.2.2]diazaoctane core, such as notoamides B and stephacidin A, were not ilolated from this feeding experiment. We isolated, however, notoamide S from cultures of Aspergillus sp. It is suggested that notoamide S is involved in biosynthesis of notoamides. Therefore, we think that notoamide S must be biosynthetic precursor.
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[Journal Article] Synthesis and Bioconversions of Notoamide T : A Biosynthetic Precursor to Stephacidin A and Notoamide B2013
Author(s)
Sunderhaus, J. D., McAfoos, T. J., Finefield, J. M., Kato, H., Li, S., Tsukamoto, S., Sherman, D. H., Williams, R. M.
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Journal Title
Org. Lett
Volume: 15(1)
Pages: 22-25
DOI
Peer Reviewed
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