2013 Fiscal Year Final Research Report
Development of on-line Raman detection system for the assistance of protein analysis
| Project/Area Number |
24710267
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Osaka University (2013)
The Institute of Physical and Chemical Research (2012) |
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Principal Investigator |
ANDO Jun 大阪大学, 工学(系)研究科(研究院), 特任研究員 (40623369)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ラマン分光法 / 薬剤標識タンパク質 / 表面増強ラマン散乱 / 質量分析法 / 液体クロマトグラフィー |
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| Research Abstract |
Functions of proteins working in a biological cell is regulated by the binding with various kinds of small molecules. Identification of specific proteins, which bind with the small molecules, and the information of their binding mechanism at molecular level, will largely contribute for the drug discovery and the study of protein function. However, complexity of biological samples often prevent to analyze them. In this research, the construction of the system was considered that can combine Raman spectroscopy with liquid chromatography. Since Raman spectroscopy has a variety of chemical information, it will contribute to analyze the samples, which are under fractionation with liquid chromatography.
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Research Products
(14 results)
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[Journal Article]2012
Author(s)
Hiroyuki Yamakoshi, Kosuke Dodo, Almar Palonpon, Jun Ando, Katsumasa Fujita, Sastoshi Kawata, Mikiko Sodeoka
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Journal Title
J. Am. Chem. Soc
Volume: Vol. 134
Pages: 20681-20689
DOI
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