Cognitive dysfunction in patients with Alzheimer's disease and amnestic mild cognitive impairment showing hemispheric asymmetries of hypometabolism on 18F-FDG PET

2014 Fiscal Year Final Research Report

• Project/Area Number: 24730594
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical psychology
• Research Institution: Kitasato University
• Principal Investigator: MURAYAMA Norio 北里大学, 医療衛生学部, 准教授 (00617243)
• Research Collaborator: ISEKI Eizo ; ENDO Tadashi ; OTA Kazumi ; KANEEDA Kyoko ; KISHIMOTO Azusa ; HIRONAKA Tomoko ; MATSUNAGA Yusuke ; YAMAGATA Mayumi
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 心理アセスメント / 認知症 / アルツハイマー病 / 記憶機能

Outline of Final Research Achievements

We investigated cognitive dysfunction in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) who present hemispheric asymmetries of cerebral metabolic rate of glucose (CMRglc) decrease on 18 F-fluorodeoxyglucose positron emission tomography. Based on the hemispheric asymmetries of CMRglc decrease in the posterior cingulate cortex, precuneus, and parietotemporal cortex, the patients were divided into three groups (a left-dominant hypometabolism group, a right-dominant hypometabolism group, and a non-dominant hypometabolism group). As a result, there were no significant differences in MMSE and WAIS-III scores among the three groups. In WMS-R, the results indicated that the left-dominant group demonstrated significantly lower scores in verbal memory than the other two groups.

Free Research Field

臨床心理学