2015 Fiscal Year Final Research Report
Behavioral study on the combination therapy of anti-dementia drug
Project/Area Number |
24730642
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental psychology
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
Yanai Shuichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60469070)
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Research Collaborator |
Endo Shogo
Arasaki Tomoko
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Keywords | 記憶・学習 / 老化 / 多剤併用療法 / シロスタゾール / ドネペジル |
Outline of Final Research Achievements |
In the present study, we revealed that the PDE3 inhibitor cilostazol improved the impaired learning and memory function in aged C57BL/6J mice and senescence-accelerated mouse prone 8 (SAMP8) to the same extent as young mice. Based on these findings, a clinical trial is now underway in Japan to gain approval for the use of cilostazol in treating mild cognitive impairment. In addition, sub-effective dose of cilostazol and donepezil in combination enhances learning and memory function in aged C57BL/6J mice. These results suggest that the combination therapy comprising two or more drugs may offer a new pharmacological approach for treating cognitive disorders, as the combination therapy demonstrated to be an effective strategy for treating some types of diseases.
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Free Research Field |
行動科学
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