2013 Fiscal Year Final Research Report
Development of novel isocyanide-based reactions
| Project/Area Number |
24750037
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 多成分反応 / イソシアニド / 複素環 |
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| Research Abstract |
In order to develop a practical method for the construction of crud like and heterocyclic compounds, we have designed a novel Passerini or Ugi reaction system where a compound (which we write in the general form as Z-X) composed of an electrophilic (Z) and nucleophilic (X) could perform the same reactivity as the carboxylic acid. Based on this concept, we have developed the O-silylative Passerini reaction and the borinic acid catalyzed addition of isocyanides to aldehydes. In addition, we have designed and demonstrated the addition reaction of isocyanides to nitrones in the presence of silly halide. Furthermore, a novel [5+1] cycloaddition of isocyanide was explored to afford the hetelocyclic compounds efficiency.
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