2013 Fiscal Year Final Research Report
Asymmetric Synthesis of Amino Acids from Carbon Dioxide
| Project/Area Number |
24750081
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
MITA TSUYOSHI 北海道大学, 薬学研究科(研究院), 助教 (00548183)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | アミノ酸 / 二酸化炭素 / 固定化 / アミノシラン / フッ化セシウム / イミン / 遷移金属錯体 / 不斉合成 |
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| Research Abstract |
A catalytic enantioselective silylation of N-tert-butylsulfonylimines using a copper-secondary diamine complex was demonstrated. The resulting optically active amino silanes could be carboxylated under a CO2 atmosphere (1 atm) to afford the corresponding amino acids in a stereoretentive manner. This two-step sequence provides a new synthetic protocol for optically active amino acids from gaseous CO2 and imines in the presence of a catalytic amount of a chiral source.
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