2013 Fiscal Year Final Research Report
Catalytic Asymmetric Synthesis of Silicon-Stereogenic Organosilanes
| Project/Area Number |
24750089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHINTANI RYO 東京大学, 工学(系)研究科(研究院), 准教授 (50372561)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 不斉ケイ素中心 / 不斉ゲルマニウム中心 / 触媒的不斉合成 / 非対称化反応 / ロジウム / パラジウム |
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| Research Abstract |
Optically active compounds constitute an important class in various field of research, and the development of efficient synthetic methods for optically active compounds has been extensively investigated to date. But most of them are directed toward the synthesis of organic compounds possessing carbon stereocenters. In contrast, catalytic asymmetric synthesis of silicon-stereogenic organisilanes has been much less explored. In this context, I worked on the development of new asymmetric catalyses involving desymmetrization of organosilicon compounds. As a result, optically active organosilanes such as dibenzosiloles and dibenzooxasilines became easily accessible.
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