2013 Fiscal Year Final Research Report
Accumulation and metabolic fate of halogenated aromatic compounds originating from preservatives
| Project/Area Number |
24750148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental chemistry
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 微量環境物質評価 / 塩素化パラベン / 代謝反応 / 代謝物 / 標品合成 / 内分泌かく乱作用 / 水生生物 / 繁殖毒性 |
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| Research Abstract |
The present study was conducted to examine the metabolic reaction and chronic effect of chlorinated parabens from a chemical perspective. The kinetic analysis indicated that chlorination of the paraben reduced its degradation rate to approximately 1/30 of that observed in the metabolic reaction with rat liver S9. We identified three novel metabolites of the chlorinated paraben and developed a practical route to their syntheses. Two metabolites, which contained a hydroxyl group, also exhibited arylhydrocarbon receptor-mediated activity in the yeast assay.
The chronic toxicity of the 12 chlorinated and nonchlorinated parabens was investigated using a 7-day Ceriodaphnia dubia test. The mortality and inhibition of reproduction tended to increase with increasing hydrophobicity and decreased with the degree of chlorination of the parabens.
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