多孔性錯体／金属ナノ結晶ハイブリッド材料による光応答型生体活性分子放出

2013 Fiscal Year Annual Research Report

• Project/Area Number: 24750201
• Research Institution: Kyoto University
• Principal Investigator: REBOUL Julien 京都大学, 物質-細胞統合システム拠点, 助教 (20604747)
• Keywords: 配位高分子 / 金属錯体 / 多孔体 / 有機無機ハイブリッド / 金ナノ結晶 / プラズモン

Research Abstract

The purpose of the research was the creation of new molecular release systems capable of remotely deliver biologically active molecules under light irradiation.
To this end, our idea was to combine the high storage ability of porous coordination polymers (PCPs), a new class of crystalline materials assembled by organic linkers and inorganic joints at the molecular scale with the photo-thermal properties of gold nanorods (GNRs) into designed mesoscopic composite materials. These new composite platforms were synthesized by applying a method developed in the applicant's group, so-called "coordination-replication", which enables to precisely control the PCP crystallization location through a dissolution-recrystallization process.
Delicate core－shell structures composed of an individual GNR core and an aluminum-based PCP shell, were thus achieved by the selective deposition of an aluminum precursor onto the surface of GNR followed by the replication of the precursor into aluminum-based PCPs.
The creation of such mesoscopic structures resulted in the implementation of unique motion-induced molecular release, triggered by the highly efficient conversion of optical energy into heat that occurs when the GNRs are irradiated into their plasmon band. Temporal control of the molecular release was demonstrated with anthracene as a guest molecule (priorly immobilized within the pores of the PCP shell) and fluorescent probe by means of fluorescence spectroscopy.
These new core-shell systems are now investigated as platforms for the release of glutamic acid and hydrogen sulfide.

Research Products

• [Journal Article] Integration of Porous Coordination Polymers and Gold Nanorods into Core-shell Mesoscopic Composites towards Light-induced Molecular Release (2013)
  • Author(s): Kira Khaletskaya, Julien Reboul, Mikhail Meilikhov, Masashi Nakahama, Stéphane Diring, Masahiko Tsujimoto, Seiji Isoda, Franklin Kim, Ken-ichiro Kamei, Roland A. Fischer, Susumu Kitagawa, Shuhei Furukawa
  • Journal Title: J. Am. Chem. Soc. Volume: 135 Pages: 10998-11005
  • DOI: 10.1021/ja403108x
  • Peer Reviewed
• [Presentation] Construction of porous coordination polymer architectures and composites by a pseudomorphic replacement process (2013)
  • Author(s): Julien Reboul
  • Organizer: 63ｒd Japan Society of Coordination Chemistry
  • Place of Presentation: Naha, Japan
  • Year and Date: 20131102-20131104
• [Presentation] Construction of porous coordination polymer architectures and composites by a pseudomorphic replacement process (2013)
  • Author(s): Julien Reboul
  • Organizer: 8th International Mesostructured Materials Symposium
  • Place of Presentation: Hyogo, Japan
  • Year and Date: 20130520-20130524
• [Book] Metal Organic Framework Materials (2014)
  • Author(s): Julien Reboul, Susumu Kitagawa
  • Total Pages: 16
  • Publisher: John Wiley