Synthesis of biomolecule using organic-inorganic hybrid capsules

2014 Fiscal Year Final Research Report

• Project/Area Number: 24760549
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Inorganic materials/Physical properties
• Research Institution: Kyushu Institute of Technology
• Principal Investigator: SHIROSAKI Yuki 九州工業大学, 若手研究者フロンティア研究アカデミー, 准教授 (40533956)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 有機－無機複合体 / カプセル / 薬物徐放

Outline of Final Research Achievements

Chitosan is a polycation and can form the polymerized membranes by the reaction with polyanions. We prepared the chitosan-silicate hybrid membranes via the sol-gel process. Their wettability, mechanical properties, and degradability were controllable by the density of cross-linking between the amino groups of the chitosan chains and the epoxy groups of GPTMS. Moreover, the hybrid membranes had excellent cytocompatibility for various cells, such as osteoblastic cells, fibroblast cells, and human gingival cells. In this study, the capsules were prepared from the chitosan-GPTMS hybrids precursor sol for the controllable releasing by the crosslinking of the chitosan matrix. And then, the capsules were modified by hydroxyapatite to improve their mechanical properties. The drug model was injected by micro manipulation methods.

Free Research Field

生体材料化学