2013 Fiscal Year Final Research Report
Evolution of gene regulatory network for eye diversification
| Project/Area Number |
24770002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Nagahama Institute of Bio-Science and Technology (2013)
The University of Tokushima (2012) |
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Principal Investigator |
OGURA Atsushi 長浜バイオ大学, バイオサイエンス学部, 准教授 (60465929)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 眼 / 進化 / トランスクリプトーム |
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| Research Abstract |
Eye is one of the most important organ but they are morphologically divorced among animals. To understand evolutionary process of camera eye in squid and pinhole eye in Nautilus, we have performed comparative transcriptome analysis of developing eyes of squid and Nautilus using next generation sequencer. First, six3/6 that are required for lens formation in vertebrates was not expressed in Nautilus. Many downstream target genes of six3/6 were also not expressed in Nautilus, suggesting that deregulation of the six3/6 pathway led to the pinhole eye evolution in Nautilus. We also found five types of Pax-6 splicing variants but no duplication of the Pax-6 gene in squid. Previous studies have reported that vertebrate eyes are controlled by four Pax-6 splicing variants, whereas eyes are controlled by duplicated Pax-6 genes. Cephalopods acquired Pax-6 splicing variants independent of those in vertebrates and that these variants were similarly utilized in the development of the squid eye.
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[Journal Article] Comparison of Gene Expression Profile of Epiretinal Membranes Obtained from Eyes with Proliferative Vitreoretinopathy to That of Secondary Epiretinal Membranes2013
Author(s)
Asato R., Yoshida S., Ogura A., Nakama T., Ishikawa K., Nakao S., Sassa Y., Enaida H., Oshima Y., Ikeo K., Gojobori T., Kono T., Ishibashi T.
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Journal Title
PLoS ONE
Volume: 8(1)
Pages: e54191
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[Journal Article] Cephalopod Genomics : A Plan of Strategies and Organization2012
Author(s)
Albertin CB, Bonnaud L, Brown CT, Crookes-Goodson WJ, da Fonseca RR, Cristo CD, Dilkes BP, Edsinger-Gonzales E, Freeman RJ, Hanlon RT, Koenig KM, Lindgren AR, Martindale MQ, Minx P, Moroz LL, Nödl MT, Nyholm SV, Ogura A., Pungor JR, Rosenthal JJC, Schwarz EM, Shigeno S, Strugnell JM, Wollesen T, Zhang G, Ragsdale CW
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Journal Title
Stand. Genomic Sci.
Volume: 7
Pages: 175–188
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